Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III

Nature, Published online: 11 June 2025; doi:10.1038/s41586-025-09090-z

An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose current production involves a laborious extraction process from yew trees.